Abstract submissions should be completed by 30 April for consideration for the conference program and bursary awards. Poster abstracts will continue to be accepted through 30 June, to be eligible for meeting-based review and innovation merit awards.
This book provides a very useful reference and comprehensive summary of all recent/current significant Alternative Testing R&D FP6/7 projects in Europe, plus additional perspectives on other initiatives e.g., in US, Japan etc. It includes a chapter on #OpenTox.
Barry Hardy PhD Director, Community of Practice & Research Activities and OpenTox Project Coordinator (www.opentox.org)
We have had a lot of activity in recent months on the OpenTox project with regards to developing a linked data and resource infrastructure for the support of interdisciplinary predictive toxicology research and safety assessment. I enclose several links below including our recent overview workshop presentation in Potsdam, reports, demonstrations, technical links and interest groups. A paper will be published as an Open Access publication in coming weeks (reference below).
We welcome your joining this community and movement to work towards the common goal of safer products and a safer environment, supported by new alternative and advanced methods.
Your Resources If you have a useful resource you would like to see integrated into OpenTox, e.g., a database from your project to which an OpenTox web service could be added, please contact me to discuss.
OpenTox Demos (Please keep in mind these are early prototype applications and may not have features you want. We welcome requests from you for what you additionally need in these applications or others.) http://www.opentox.org/toxicity-prediction
Publication Reference Collaborative Development of Predictive Toxicology Applications, B. Hardy, N. Douglas, C. Helma, M. Rautenberg, N. Jeliazkova, V. Jeliazkov, I. Nikolova, R. Benigni, O. Tcheremenskaia, S. Kramer, T. Girschick, F. Buchwald, J. Wicker, A. Karwath, M. Gütlein, A. Maunz, H. Sarimveis, G. Melagraki, A. Afantitis, P. Sopasakis, D. Gallagher, V. Poroikov, D. Filimonov, A. Zakharov, A. Lagunin, T. Gloriozova, S. Novikov, N. Skvortsova, D. Druzhilovsky , S. Chawla, I. Ghosh, S. Ray, H. Patel, S. Escher, accepted 3 June 2010 for Open Access publication in J. Chemical Informatics http://www.jcheminf.com/ (2010).
The OpenTox workshop on "Satisfying REACH
Requirements in Predictive Toxicology" to be held at the ISS in Rome 10-11 September 2009.
Participants at the workshop will involve cross-industry users
and regulatory experts in addition to solution developers and providers who will
discuss the requirements and use cases of users in chemical toxicology
evaluation and risk assessment, and including satisfaction of current and future
requirements of the REACH legislation using alternative testing methods. The
workshop format involves short presentations to provide user, regulatory and
solution needs perspectives, followed by knowledge cafe discussions discussing
use cases, challenges, issues, solutions, collaboration opportunities and ways
forward in small groups.
Introduction & Workshop Overview, Barry Hardy (OpenTox and Douglas Connect,
Use of Computational Methods for the in
silico Prediction of Chemical
Properties in REACH, Andrew P Worth (Systems Toxicology Unit, Institute for
Health and Consumer Protection, European Commission -Joint Research Centre, Italy)
09.40 Automated Workflows for Hazard Assessment, Elena
Fioravanzo (S-IN Soluzioni Informatiche, Italy)
10.05 OpenTox Predictive Toxicology Use Cases, Barry
Hardy (OpenTox and Douglas Connect, Switzerland)
11.00 Knowledge Café Discussions
12.30 Group Discussion
Opportunities for using Systems Biology Data for in silico Modeling of
Personalized Medicine, Richard D.
Beger (Division of Systems Toxicology,
National Center for Toxicological Research, Food and Drug Administration, USA)
14.25 A Framework for
Using Structural, Reactivity, Metabolic and Physicochemical Similarity to
Evaluate the Suitability of Analogs for SAR-based Toxicological Assessments, Joanna Jaworska (Procter &
Gamble, Modeling & Simulation, Biological Systems, Brussels Innovation Center, Belgium)
of Integrated Assessment Tools for Environmental Risk Assessment, Willie
Peijnenburg (National Institute for Public Health and
the Environment, The Netherlands)
15.15 Prediction of Animal
Toxicity Endpoints for ToxCAST Phase I Compounds using a Combination of
Chemical and Biological in vitro
Descriptors, Alex Tropsha (Carolina Center for Computational
Toxicology and Carolina Environmental Bioinformatics Research Center,
University of North Carolina at Chapel Hill, USA)
15.40 Coffee Break
16.00 Knowledge Café
17.30 Group Discussion
Predictive Toxicology for Cosmetics - An
Industry Perspective, Stephanie
Ringeissen (Safety Research Department, L’Oréal R&D, France)
Specialty Chemical Industry Perspective on Predictive Toxicology, Maurizio Colombo (Health & Safety Evaluation, Industrial
Regulation Management, Lamberti S.p.A., Italy)
10.45 Knowledge Café Discussions
12.00 Group Discussion
The Italian Chemical Industry and the REACH
impact on SMEs, Antonio Conto (Chemsafe Srl, Italy)
and Regression-Based QSAR of Chemical Toxicity on the Basis of Structural and
Physicochemical Similarity, Oleg Raevsky (Department of Computer-Aided
Molecular Design, Institute of Physiologically Active Compounds of Russian
Academy of Sciences, Moscow, Russia)
of Toxcast Data and in vitro / in vivo Endpoint Relationships, Romualdo
Benigni (Istituto Superiore di Sanità, Italy)
When I started the eCheminfo community of practice in late 2003 we focused initially on using the approach of virtual conferencing and communications to get the community started. More recently I have given more attention to developing face-to-face conference and workshop activity and initiating collaborative research. While on this journey it has been personally rewarding to have met and made contact with hundreds of scientists in the international community and to additionally be involved in supporting their networking, career development and research in drug design, discovery and modelling. It has also been rewarding to have just met so many great people and to have had the chance to interact with them, be it on a computer, in a workshop exercise, or on a punt trying to get down the river as we usually do when we are in Oxford. So far we seem to be better on computer-based physics than boat physics!
And so I have come full circle and can see the need to prioritise the virtual community aspects of eCheminfo further again, to support the continuation of all these worthwhile interactions in the community. So LinkedIn is one place to start. I have been on there for some years and we have had a group area, but have not really done much with it. It has primarily been useful for some introductions between people. However recent feature additions for discussion, posting of news, job announcements etc. have been added, so it seems worthwhile to try using it more for supporting continuing interactions in the community. So I am initiating today invitations to the eCheminfo community to join us there for discussion, news and networking on what is happening in the world of drug discovery informatics, cheminformatics, bioinformatics, etc. Use of the group is intended for scientific and professional exchange purposes only. As included in our mission we encourage cross-disciplinary cross-sector participation so from medicinal chemists in the pharmaceutical industry through toxicologists in government institutes through PhD students working on their modelling research problems are welcome!
To request joining the eCheminfo LinkedIn group please follow the following link and introduce yourself with a group joining request: