eCombiChem Leads

Combinatorial Screening of Polymeric Coating Formulations

Jaime Grunlan, Senior Research Engineer, Avery Research Centre, will present the following seminar at the eCombiChem “Cutting Edge Technologies in Combinatorial Chemistry” Web Conference running at http://ecombichem.com/, and opening 20th September 2004:

Combinatorial Screening of Polymeric Coating Formulations

A combinatorial factory for the preparation and screening of polymeric coatings is outlined here. The coating formulations are prepared and coated using a novel combinatorial coating technique to obtain combinatorial libraries of varying composition and thickness. The thickness of each film in a combinatorial array is rapidly determined via visible-light absorbance of optical dyes in conjunction with the Beer-Lambert relationship. These combinatorial libraries are then tested and screened using a variety of custom-made high-throughput methods. Combinatorial screening of oxygen and moisture transmission rate, along with pressure-sensitive adhesive properties, is presented. OTR and MVTR are determined using spectrometric techniques. For adhesion, a spherical probe adhesive tester is able to generate parameters linked to tack, peel, and shear in one measurement. In addition to describing the testing methodology, benefits and shortcomings of these techniques will be highlighted.

Barry Hardy
Douglas Connect
www.douglasconnect.com
Cutting Edge Technologies in Combinatorial Chemistry: http://ecombichem.com/
ECombiChemLeads Blog: http://barryhardy.blogs.com/ecombichemleads/

Application of microchannel flowreactors for lead optimization and library development

Ferenc Darvas, Ph.D., President and Chairman, ComGenex, Inc. will present the following seminar at the eCombiChem “Cutting Edge Technologies in Combinatorial Chemistry” Web Conference running at http://ecombichem.com/, and opening 20th September 2004:

Application of microchannel flowreactors for lead optimization and library development

Combinatorial chemistry is a target/oriented, adaptive science that is now facing the challenge of fast developing fields such as micro and nanotechnologies. The drive towards miniaturization has several advantages, namely speed, increased reaction sensitivity and control and cost effectiveness.

An important development has been the utilization of microfabricated devices such as microchannel flow reactors for synthesis of general and focused libraries as well as for lead optimization. These micro devices can be defined as a series of minute interconnecting channel reactors in which chemical reactions are performed in a continuous flow. Continuous methods are widely used in chemical synthesis due to their lower operating costs and high efficiency, their main drawbacks being size, high set up costs and lack of flexibility. The development of continuous micro channel flowreactors has the potential to overcome these disadvantages due to their higher yields, and reaction selectivity and control, leading to an enhancement of both productivity and performance of combinatorial library synthesis, together with other unusual chemical and operation opportunities.

Microchannel flowreactors can perform standard homogenous, or heterogeneous, gas/solid/liquid phase reactions, which represent an efficient method for parallel synthesis of combinatorial libraries. A substantial increase of the reaction rate relative to the batch liquid phase reaction is generally achieved, thus allowing a faster synthesis of more and often highly purified compounds.

These microchannel flowreactors are safe and convenient to use in any laboratory and they are compatible with widely available robotic equipment. After a number of optimization rounds, the device can be used for any chemical synthesis under the desired conditions.

In this presentation an overview will be given on this rapidly developing field with specific examples as well as future trends described.

Barry Hardy
Douglas Connect
www.douglasconnect.com
Cutting Edge Technologies in Combinatorial Chemistry: http://ecombichem.com/

Welcome to the eCombiChem Conference.

Words from the chair:

We are proud to welcome the scientific community to the first virtual conference in the area of combinatorial chemistry (September 20-30, 2004) taking place at http://ecombichem.com/. The internet and related technology has matured to the point that now scientists can use the internet more effectively for what it was initially designed to do: Promote and facilitate the interaction among scientists for faster and more effective communication of ideas and information for research.

eCombiChem Leads Blog

This eCombiChem Leads Blog has been created to provide news and views from the world of combinatorial chemistry and is a companion to our newly launched eCombiChem.com community and conferencing site.

Barry Hardy
Douglas Connect
www.douglasconnect.com

and

Guillermo Morales
Morales Consulting
www.CombiChemlab.com