The Ferryman

ToxBank Infrastructure - paper available in Open Access

The following publication is now available in Open Access:

The ToxBank Data Warehouse: Supporting the Replacement of In Vivo Repeated Dose Systemic Toxicity Testing

Pekka Kohonen, Emilio Benfenati, David Bower, Rebecca Ceder, Michael Crump, Kevin Cross, Roland C. Grafström, Lyn Healy, Christoph Helma, Nina Jeliazkova, Vedrin Jeliazkov, Silvia Maggioni, Scott Miller, Glenn Myatt, Michael Rautenberg, Glyn Stacey, Egon Willighagen, Jeff Wiseman, and Barry Hardy

Molecular Informatics
Special Issue: Advances in Computational Toxicology

Volume 32, Issue 1, pages 47–63, January 2013

http://onlinelibrary.wiley.com/doi/10.1002/minf.201200114/abstract

C4C cell therapy industrialisation initiative

C4C cell therapy industrialisation initiative in France pursues public-private partnership approach and establishes large scale production facility for cell-based therapeutics.

http://www.businesswire.com/portal/site/home/permalink/?ndmViewId=news_view&newsLang=en&newsId=20121021005017&div=16486113

Free downloads are available on new safety evaluation research aiming to replace animal testing

Free book downloads are available on our predictive toxicology research
carried out within the public private partnership of SEURAT (Safety
Evalua tion Ultimately Replacing Animal Testing) -1 (where 1 indicates the first phase of 5 years).
 
The SEURAT-1 annual books called "Towards the replacement of in vivo
repeated dose systemic toxicity testing", aim to inform policy makers
about scientific progress relevant to the implementation of European
Directives and Regulations and about essential gaps in knowledge
corresponding to research needs.

http://www.seurat-1.eu/pages/library/seurat-1-annual-report.php

New Human Induced Pluripotent Stem Cell Initiative (HIPSCI)

Wellcome Trust and MRC invest £13 million to create a new national stem cell resource.

http://www.eurekalert.org/pub_releases/2012-11/wt-wta110512.php

Drug shows clinical benefit in maintenance of cognitive function in Alzheimer’s disease patients

Drug antagonising the Receptor for Advanced Glycation Endproducts (RAGE) pathway is shown to provide clinical benefit in maintenance of cognitive function in Alzheimer’s disease patients. The drug acts, in part, by restoring the normal balance of amyloid protein transport into and out of the brain. 
 
(Note on tox/clinical trial halting "...although individuals enrolled
in the trial at the highest tested dose experienced signs of toxicity,
those effects were reversible, and the lower dose resulted in the
benefits and lack of adverse events reported here...")

http://www.drugdiscoveryonline.com/doc.mvc/novel-oral-drug-disease-modification-alzheimer-s-patients-0001?sectionCode=News&templateCode=EnhancedStandard&user=1935203&source=nl%3A35474

A Shared Moment of Great Happiness

Barry Hardy and Spela Predan, Just Married.

 

OpenTox 2011 Technical Reports

The following #OpenTox 2011 technical reports in predictive toxicology are available for downloading:

OpenTox D1.4 Report on Evaluation of the Final Implementation

OpenTox D2.4 Report on Final Framework

OpenTox D3.4 Report on Final Database with Additional Content

OpenTox D4.3 Report on Final Version of (Q)SAR algorithms

OpenTox D5.3 Report on Validation Against Confidential Data

OpenTox D5.4 Report on Final Validation Routines with Facilities to Validate Against Confidential Data

Predictive Toxicology Ontology Perspectives and Roadmap

Re: #OpenTox, ontology, new predictive toxicology systems

The following papers are now available from the new issue of Altex:

Toxicology ontology perspectives
This article provides an overview of some of the leading developments in
incorporating ontology into new knowledge-based systems in predictive toxicology.

http://www.altex.ch/en/index.html?id=16&aid=3

A toxicology ontology roadmap
In this article we lay out the main justifications and needs for ontology
development to enable the building of interoperable predictive toxicology systems
and services for industry to design and test safer products.

http://www.altex.ch/en/index.html?id=16&aid=2

OpenTox Toxicology Ontology Development

This article is just out online describing initial #OpenTox ontology work:

#OpenTox predictive toxicology framework: toxicological ontology and semantic media wiki-based OpenToxipedia

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337268/

Our Valentine's Message to you today Nicki

Our love is a little more painful today Nicki but we will continue to be inspired by your spirit and vision in times to come. Tonight let's first close our eyes and talk with you as we enter the early hours and your dancing begins. Let the cats of the world gather around in the deep of the night with us and see again that yes there is a planet still alive and not yet quite amused to death.

 

 

 

All my Love Barry