I provide below a schedule for the upcoming InnovationWell and eCheminfo Community of Practice meetings at Bryn Mawr.
I also include a location map here which may be useful upon arrival:
Download bryn_mawr_campus_map_douglas_connect_meeting.pdf
[Please follow continuation here to view schedule.]
Current advances in computer-based predictive toxicology offer the potential to create more advanced environments for the screening and prediction of safety issues due to chemical and drug adverse side effects, drug-drug and chemical-system interactions, and chemical and drug toxicologies in the environment and the human body. Advances in this growing field also offer the potential to replace or reduce the need for animal testing and to reduce later stage clinical trial failures or new product development rejection. Acceleration of progress in practical applications requires the creation of interoperable environments, knowledge sharing, data integration, algorithm development, and extensive validation and testing.
Numerous opportunities exist in this field for scientific advances, but also for innovation, service and product development, and value creation. Additionally, significant collaboration approaches are a scientific, industry and society imperative to advance this field and the safety of new products and all society members. Collaborative approaches need to support the multidisciplinary networking and collaboration between computer scientists, biologists, chemists, toxicologists, product development and clinical and environmental researchers, and to network groups, centers, initiatives, projects and data into interoperable semantic frameworks, systems, knowledge bases and virtual organisations.
At our Predictive Toxicology session chaired by Artem Cherkasov (University of British Columbia) running 17 October 2008 at Bryn Mawr recent developments in the field of predictive toxicology will be presented and discussed.
The session will be preceded the evening of October 16 by a Knowledge Café to discuss Collaboration Opportunities in Predictive ADME & Predictive Toxicology.
A description of the session with presentation abstracts follows. Please add your comments, discussion or questions at the end of the post.
Predictive Toxicology
(Please follow continuation here to read abstracts. Comments can be made at the end.)
The prediction of absorption, distribution, metabolism, and excretion (ADME) properties has become increasingly important as failures late in the drug discovery process become more costly. Increasingly, stringent in vitro and in vivo requirements have been placed on the hit-to-lead and lead optimization stages of the drug discovery process. Although it is tempting to dismiss ADME modeling and simply conduct an in vitro or in vivo experiment to get “the correct answer”, this approach is not practical. A skilled, competent medicinal chemist working on a lead optimization program can easily conceive of far more compounds than can reasonably be synthesized during the time of a lead optimization effort. In vivo studies are expensive and time-consuming and may become the rate-limiting step for some projects, particularly for small pharmaceutical companies. Rather than providing “the correct answer”, modeling provides a means of “stacking the deck” in favor of the medicinal chemistry effort, increasing the likelihood that a given compound will show the desired effect in vitro or in vivo.
At our Predictive ADME session chaired by Anthony Klon running October 16 at Bryn Mawr recent developments in the predictive modeling of ADME properties will be presented and discussed. Speakers will present their research into modeling microsomal stability, drug-drug interactions, and membrane transport processes such as blood-brain barrier penetration, intestinal absorption, and skin penetration. One topic of the accompanying discussions will be the appropriateness of relevant biological endpoints for ADME/PK modeling.
The session will be followed in the evening by a Knowledge Café to discuss Collaboration Opportunities in Predictive ADME & Predictive Toxicology.
A description of the session with presentation abstracts follows. Please add your comments, discussion or questions at the end of the post.
Predictive ADME
http://innovationwell.net/COMTY_confprogr08adme
(Please follow continuation here to read abstracts. Comments can be made at the end.)
Continue reading "Predictive ADME: guiding the lead development and optimization process" »
Healthcare is a highly complex, information-driven industry, and effective knowledge management is at the heart of the drug discovery and development process. Translational medicine is becoming increasingly important within the pharmaceutical industry where it is defined by a variety of initiatives designed to facilitate the transfer of knowledge from the bench to the bedside and back.
On the 15 October 2008 at the InnovationWell Community of Practice Meeting at Bryn Mawr College, Philadelphia, I will chair a day-long session where we have brought together a diverse set of speakers representing a broad spectrum of activities across the pharmaceutical workflow – from target identification to clinical trials. Each presentation will describe specific examples of advances in translational medicine brought about by practical approaches to improved knowledge management. Sometimes these advances will be technology-based, sometimes they will have resulted from innovative forms of collaboration and the use of Web 2.0 tools. Together we hope these speakers will stimulate discussion and the transfer of insights and ideas illustrating the potential of knowledge management tools and techniques to drive advances in translational medicine.
A description of the session with presentation abstracts follows:
Knowledge Management in Translational Medicine
http://innovationwell.net/COMTY_confprogr08kmtransmed
(Please follow continuation here to read abstracts. Comments can be made at the end.)
Continue reading "Knowledge Management in Translational Medicine" »
This year's InnovationWell Autumn Community of Practice Meeting will take place 14-17 October 2008 at Bryn Mawr College, Bryn Mawr, Philadelphia, USA to discuss the following areas of Innovation in Life Science & Healthcare R&D:
Critical Path Advances in Drug Development, Innovation & Knowledge Management in R&D and Translational Medicine, Computational Biology, Predictive ADME, Predictive Toxicology, Metabolomics, Biomarkers, Systems Biology
Program Summary
Systems Biology, chaired by Keith Elliston (Genstruct)
Computational Biology, chaired by Debraj Guhathakurta (Merck)
Knowledge Management in Translational Medicine, David Bousfield (Ganesha Associates)
Applications of Metabolomics to Drug Discovery & Development, chaired by Bruce Kristal (Brigham and Women's Hospital)
Predictive ADME, chaired by Anthony E. Klon (Pharmacopeia Drug Discovery)
Predictive Toxicology, chaired by Artem Cherkasov (University of British Columbia)
Pre-Conference Workshop, 13 October 2008
Knowledge Management in R&D
chaired by John Conway (Accelrys) and Frank Hollinger (FRESH Directions Consulting)
Speakers
Keith Elliston (Genstruct), Debraj GuhaThakurta (Rosetta Inpharmatics, Merck & Co.), Stephen W. Edwards (U.S. Environmental Protection Agency), Paul McDonagh (Gene Network Sciences), Christopher M.L.S. Bouton (Pfizer), James R. Brown (GlaxoSmithKline), John Wilbanks (Creative Commons), Barry Bunin (Collaborative Drug Discovery), Michael Liebman (Windber Research Institute), Jerry Wright (Johns Hopkins Medical Institutions), Anastasia Christianson (AstraZeneca), James Golden (Science Applications International Corporation), John Speakman (National Cancer Institute), William Hayes (Biogen Idec), Andrew McMurry (Harvard Medical School), Eugene Clark (Partners Healthcare), Alvin Berger (Metabolon), John Newman (USDA), Bruce Kristal (Brigham and Women's Hospital), Anton Hopfinger (University of New Mexico), Heidi Einolf (Novartis), Yojiro Sakiyama (Pfizer), Olga Obrezanova (BioFocus DPI, UK), Anthony E. Klon (Pharmacopeia), Artem Cherkasov (University of British Columbia, Canada), Ann Richards (US EPA), Curt Breneman (RPI), Alex Tropsha (UNC), Barry Hardy (Douglas Connect), Weida Tong (FDA)
CFP
We invite contributed papers from members of academic, government research and commercial organizations on areas of new research and innovation relevant to innovation and knowledge management in the life sciences. The work presented should involve innovative new method development or application in the areas of systems biology, translational medicine, knowledge management, computational biology, metabolomics, predictive ADME, predictive toxicology or bioinformatics. Studies including experimental work in medicinal chemistry, screening, experimental toxicology, pre-clinical evaluation, lead optimisation and translational medicine are welcome.
Abstracts (300-500 words) should be submitted to innovationwell -[at]-douglasconnect.com by 31 July 2008, and be accompanied by a short biography of the presenting author (300-500 words). Abstracts approved by the scientific organizing committee will be selected for scheduling on the conference program and in meeting poster sessions. Authors will be notified of acceptance as soon as a review of submitted materials takes place and at the latest by 15 August 2008.
Bursary
Bursary Awards will be used to support the attendance of a selection of academic young investigators at the meeting and workshops. Applicants should be working in a relevant area of research related to life science, healthcare, and drug product discovery and development at the postdoctoral, graduate student and senior undergraduate levels.
To apply for the bursary please send an email with a) your abstract and biography (300-500 words each), b) your CV of 1-2 pages, c) a short description of your interests and career motivations related to R&D (300-500 words) to innovationwell -[at]- douglasconnect.com by 31 July 2008. The recipients of the bursary awards will be selected based on an evaluation of the quality and innovation of the described research and the potential positive impact of attendance at the meeting on their research and career progress. Authors will be notified of acceptance by 15 August 2008.
Poster Session
All InterAction Meeting registrants are eligible to present a Conference Poster. The Poster Sessions will take place in the evenings in Thomas Great Hall on campus, where refreshments and dinner are also served. Poster Abstracts (300-500 words) with Title, Institution, Authors and Contact Information should be submitted to barry.hardy -[at]-
douglasconnect.com Abstracts will be considered based on date of submission and quality, and will be reviewed and accepted as they are received. To be considered for the formal program, they should be submitted at the very latest by 31 August 2008.
Download Program Brochure as pdf:
Download InnovationWell-BM08-Final1.pdf
Contact:
Program: Dr. Barry Hardy, InnovationWell Community of Practice, Douglas Connect. Tel: +41 61 851 0170. barry.hardy -[at]- douglasconnect.com
Registration Enquiries: Nicki Douglas, Douglas Connect, Baermeggenweg 14, 4314 Zeiningen, Switzerland. Tel: +41 61 851 0461. InnovationWell -[at]- douglasconnect.com or please visit:
InnovationWell meeting Computational Biology Translational Medicine Systems Biology ADME Predictive ADME Predictive Toxicology Innovative Medicines Community of Practice workshop conference management executive Bryn Mawr Philadelphia Critical Path biomarkers metabolomics toxicology personalised medicine KM Life Sciences Pharma Drug Discovery Drug Safety Research and Development Drug Development Healthcare Innovation Knowledge Management events
We are holding a Knowledge Cafe and networking event at the Merian Hotel, Basel, Switzerland 17.00-20.00, Wednesday 23 April 2008, on the topic of Knowledge & Collaboration.
We will additionally extend the use of supporting the face-to-face cafe conversations with the virtual collaboration tool of a wiki as I used at the Autumn 2007 InnovationWell meeting at Bryn Mawr. (more information on that in a later post)
The Café discussions will be peer-to-peer based and will be co-moderated by:
Beat Knechtli, Director and CKO, PricewaterhouseCoopers
Pavel Kraus, President, Swiss Knowledge Management Forum and Senior Partner, aht'intermediation
Douglas Weidner, President, International Knowledge Management Institute
Barry Hardy, Founder and Director, InnovationWell & Douglas Connect
Chris Pallaris, ISN Chief Editor, Swiss Federal Institute of Technology (ETH Zurich)
Hannes Gassert, CTO, Liip
Nicolette Liller, Microsoft
Asha Nagesser, Managing Director, INSIDEAN
Marco Bettoni, Director of Research & Consulting, Swiss Distance University of Applied Sciences (FFHS)
Richard Zbinden, CEO, Software for Corporate Leaders
The following Guest Seminar will be presented:
17.00 Process-Oriented Knowledge Management
Michael Wyrsch, Vice-President & Leader of the Knowledge Management Competence Center Switzerland, Credit-Suisse
During the Café starting at 18.00, table discussions will include the following Knowledge & Collaboration sub-topics:
Knowledge Sharing, Innovation Networks, Leadership Support, Organisational Complexity & Context, Productivity & Teams, Group Decision-Making, Collaboration Patterns & Roles, Social Networks and Web 2.0, Culture & International Collaboration, and Cooperative Sustainable Development.
The Cafe is free to attend. Light refreshments will be provided. If interested in attending please contact Nicki Douglas (Tel: +41 61 851 0461. Email: Nicki.Douglas –(at)- douglasconnect.com) to reserve a guest place.
The event is co-organised by Douglas Connect, the International Knowledge Management Institute, the Swiss Knowledge Management Forum (SKMF), and the Gurteen Knowledge Community.
Knowledge & Leadership
In 2007 the Basel Knowledge Café focused on *Knowledge & Leadership* whose results formed the basis for an article series being published in KM Review:
B. Hardy; Linking Trust, Change, Leadership & Innovation – Ingredients of a Knowledge Leadership Support Framework; KM Review, Nov/Dec 2007, Vol 10, Issue 5, pp 18-23.
B. Hardy; Collaboration, Culture, and Technology – Contributions to Confidence in Leadership Support; KM Review, Jan/Feb 2008, Vol 10, Issue 6, pp 18-23.
A short summary with photos is posted on the The Ferryman Blog at http://barryhardy.blogs.com/theferryman/2007/06/knowledge_and_l.html
The Café also contributed significantly to the formation of the KLeaders practice and interest group, which has since been working together on developing the ideas of the KLeaders Leadership Practice and Support Framework, and which is currently collaborating on research and network proposals. If you are interested in this research and innovation activity, please contact Dr. Barry Hardy (barry.hardy –(at)- douglasconnect.com, +41 61 851 0170) to discuss your needs or contributions.
Knowledge Collaboration Leadership Knowledge Cafe Douglas Connect KM Institute KM Institute Switzerland meeting workshop training management executive CKM KM Knowledge Management Knowledge Management Training Management Training Basel Innovation Switzerland events
On the morning
of 16 October 2007 as part of our InnovationWell workshop on Information,
Communications, and Knowledge Management Support Systems for R&D (Bryn Mawr College, Philadelphia) we will hold an emerging technologies session featuring the presentation and
discussion of a range of interesting software solutions.
(Please
follow continuation to read)
Continue reading "Emerging ICT Technologies for R&D Support" »
On the 17-19 October 2007 we will host a joint
eCheminfo and InnovationWell Community of Practice Workshop and Forum at Bryn Mawr College, Philadelphia to discuss and advance
best practices in predictive ADME and Toxicology, to develop best practices for
comparison studies and validation, to review latest developments in method
development and applications related to drug discovery and development, and to
discuss the potential for collaborations between initiatives and international
cooperation.
This conference, forum and
workshop activity will consist of the following parts:
1. Workshops to discuss developments, challenges and potential for collaborations. (afternoons of October
17-19).
2. Conference
sessions on latest ADMET methods and application developments with
presentations and panel discussions. (mornings of October 18 and 19)
3. Hands-on Workshop
sessions with drug discovery informatics software (running during afternoons throughout week)
4. Evening Poster Sessions on latest modelling
developments (evenings of October 17 and 18)
Workshop
Facilitators
Joseph Tomaszewski (NCI), Artem Cherkasov
(University of British Columbia), Dennis Pelletier (Pfizer), Richard Beger
(FDA), Anthony Klon (Pharmacopeia Drug Discovery), Tony Hopfinger (University
of New Mexico College of Pharmacy), Joseph Contrera (FDA), Christoph
Helma (University of Freiburg and in silico toxicology), Vladimir Poroikov
(Russian Academy of Sciences), Judith Madden (Liverpool John Moores
University), Ann Richard (EPA)
(continued ...)
Continue reading "Advancing best practices in predictive ADME and Toxicology" »
Is knowledge management a science? How should we define it? These questions may look simple but are not so easy to answer for both individuals and the collective. How can we apply the scientific method in a constructive way to knowledge management activities such as successfully managing communities of practice, transforming community of practice activity to community of innovation activity, or building next generation IT systems for the more successful support of knowledge management activities such as organisational culture transformation, innovation, change management, collaboration, sustainable trust between stakeholders, and leadership transparency? (as discussed in our Knowledge Cafe last week in Basel (agenda)
(If interested in this topic and wishing
to add to the discussion, please follow the links and read on!)
A variety of initiatives of relevance to the development of ADME/Toxicology resources of value to supporting improved productivity in drug discovery and development are in progress in different organisations and countries. There is potential for great benefits for collaboration and alignment between such initiatives so as to support the robust development of the emerging field of predictive toxicology and to advance goals related to heathcare safety and development as expressed in the FDA's Critical Path Initiative in the USA and the EU's Innovative Medicines Initiative in Europe.
To further development and progress in this area we are scheduling the following activity:
International Forum & Workshop on Cooperation on ADME/Tox
18-19 October 2007
to take place at the Community of Practice Meeting, Autumn 2007
a joint InnovationWell and eCheminfo InterAction Meeting
Bryn Mawr College, Philadelphia
http://www.echeminfo.com/COMTY_conferences
This forum and workshop will have an agenda developed by workshop leaders to address ways forward for international cooperation and including discussion of the following topics:
The agenda of the forum and workshop will be designed by a set of workshop leaders so as to maximise interaction, discussion, issue resolution, and action plans for cooperation. In addition to presentations on latest developments, workshop activities will address specific challenges to progress in the field and areas where collaboration can support integration and alignment of programs and resources and reduction of duplication. An Innovation Cafe format will be used in which the group will define a scenario in which optimum confidence in predictive toxicology methods has been reached and will then prioritize steps for achieving that goal. The resulting roadmap should provide action plans where cooperation between initiatives can accelerate the contribution of predictive toxicology methods to enhanced confidence in safety of new healthcare products and progressing the goal of reduction and replacement of animal testing by computational methods. Virtual communication and collaboration approaches will be used pre- and post-event to maximise the benefit of the workshop.
Workshop leaders are being invited from the US and Europe and will include representatives from industry, government and academia.
Barry Hardy
Community of Practice Manager
eCheminfo InnovationWell cheminformatics chemoinformatics bioinformatics Medicinal Chemistry Computational Chemistry Virtual Screening ADME ADMET toxicology Molecular Modelling Molecular Modeling pharmaceutical pharma meeting workshop training Oxford Critical Path toxicology Bursary Life Sciences Pharma Drug Discovery Research and Development Drug Development Healthcare Innovation Knowledge Management events
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