The background of developing Open Standards, Open Specifications and related Open Source Components with OpenTox provides a valuable foundation on which we are developing ToxBank as a reference extensible architecture for predictive toxicology.
I suggested OpenTox is developing itself as an Open Knowledge Community supporting accelerating innovation through knowledge sharing, application development, semantic interoperability and ontology for combining data and models, and learning from the application of developed tools to problem solving.
We are interacting with many partners on the SEURAT-1 program providing a rich context for requirements gathering, design and implementation, working closely with the evolving needs and development goals of the program.
We have been working on putting in place best practices on the description of data, and importantly the protocols used to generate and process that data.
I suggested it is also a priority that this practice includes the contributions of computational science and integrated analysis, and I encouraged both the OpenTox community and the ToxBank development to progress this important goal.
The above approaches provide a foundation on which we can integrate many advances in integrated analysis, systems biology, in vitro assay development, omics, and bioengineeering to support an event driven Weight of Evidence approach and semantic reasoning across ontology-linked heterogenous evidence.
You can download a copy of the slides here as a pdf:
We will be joined by presenters from many leading US research programs
including ToxCast, Tox21, US EPA, NIEHS, NTP, NIH, US FDA, Risk21,
Hamner and John Hopkins.
The meeting is organised in collaboration with ToxBank and will include
participation from SEURAT-1 European research programs including
HeMiBio, COSMOS, NOTOX, and ToxBank.
The meeting should provide a valuable opportunity to progress transatlantic goals on interoperability and collaboration supporting
SEURAT-1 - Tox21 interactions based on concrete activities related to data resource interoperability, open standards, software development,
modelling and integrated analysis.
We will also specifically address key îssues of extrapolation, kinetics modelling and risk assessment application providing roadblocks to be
removed from the path to regulatory acceptance.
The OpenTox USA 2013 community meeting on innovative developments and
applications in predictive toxicology will take place in RTP, North
Carolina 29 - 30 October. The meeting is being organised as a
collaboration between OpenTox and ToxBank.
The meeting provides an opportunity for researchers to learn about best
practices and new applications in data management, modelling and
analysis applied for predictive toxicology and risk assessment purposes.
Abstracts for the poster session are being accepted through 30 September.
On behalf of the OpenTox USA 2013 Organising Committee,
we look forward to seeing you in Raleigh-Durham.
Barry Hardy (Douglas Connect)
Scott Auerbach (NIEHS)
Rusty Thomas (Hamner Institutes)
Asish Mohapatra (Health Canada)
OpenTox USA 2013
Hamner Conference Center, North Carolina Biotechnology Center
29 - 30 October
Topics: data management, in silico modelling and application
development, integrated data analysis, biokinetics, cheminformatics,
bioinformatics, weight of evidence, risk assessment.
We will run our international Knowledge Management Training week again in Switzerland 6-10 May 2013.
Knowledge Management (KM) Concepts, KM Practices,
Business Case, Strategy, Program Planning, KM
Frameworks, KM & Organisational Culture &
Development, Change Management for KM Programs,
Leadership and Competencies for KM Knowledge
Assessment, Metrics, Enterprise Knowledge
Management, Process-oriented Knowledge Management,
Knowledge Mapping, Benchmarking, Expertise
Location, Search, Personal Knowledge Management,
Web 2.0, Communities, Collaboration
A toxicology ontology roadmap In this article we lay out the main justifications and needs for ontology development to enable the building of interoperable predictive toxicology systems and services for industry to design and test safer products. http://www.altex.ch/en/index.html?id=16&aid=2
I look forward to that future "Sixth Sense" journey interoperating with OpenTox to revisit the Tamboti Trees in South Africa and the Mopane Trees in Namibia, and to test the delivery of safety advice from the distributed semantic knowledge of OpenTox 3.0 use cases in the field :)!