A variety of initiatives of relevance to the development of ADME/Toxicology resources of value to supporting improved productivity in drug discovery and development are in progress in different organisations and countries. There is potential for great benefits for collaboration and alignment between such initiatives so as to support the robust development of the emerging field of predictive toxicology and to advance goals related to heathcare safety and development as expressed in the FDA's Critical Path Initiative in the USA and the EU's Innovative Medicines Initiative in Europe.
To further development and progress in this area we are scheduling the following activity:
International Forum & Workshop on Cooperation on ADME/Tox
18-19 October 2007
to take place at the Community of Practice Meeting, Autumn 2007
a joint InnovationWell and eCheminfo InterAction Meeting
Bryn Mawr College, Philadelphia
http://www.echeminfo.com/COMTY_conferences
This forum and workshop will have an agenda developed by workshop leaders to address ways forward for international cooperation and including discussion of the following topics:
- latest advances in QSAR and ADME/Tox methodologies and resources
- impact of government and regulatory policy and legislation in the US and Europe
- potential and barriers for replacing animal testing by alternative approaches
- actions for data integration and knowledge sharing between initiatives
- the role of semantic web approaches in uniting structured data from multiple resources
- the role of natural language processing for processing unstructured information
- extraction of data from the scientific literature
- methods and procedures for secure testing of commercial data that could be acceptable to industry
- application of advanced search and agent technologies
- frameworks for computational model testing and validation
- impact of knowledge management approaches
- collaboration and community support structures and environments
The agenda of the forum and workshop will be designed by a set of workshop leaders so as to maximise interaction, discussion, issue resolution, and action plans for cooperation. In addition to presentations on latest developments, workshop activities will address specific challenges to progress in the field and areas where collaboration can support integration and alignment of programs and resources and reduction of duplication. An Innovation Cafe format will be used in which the group will define a scenario in which optimum confidence in predictive toxicology methods has been reached and will then prioritize steps for achieving that goal. The resulting roadmap should provide action plans where cooperation between initiatives can accelerate the contribution of predictive toxicology methods to enhanced confidence in safety of new healthcare products and progressing the goal of reduction and replacement of animal testing by computational methods. Virtual communication and collaboration approaches will be used pre- and post-event to maximise the benefit of the workshop.
Workshop leaders are being invited from the US and Europe and will include representatives from industry, government and academia.
Barry Hardy
Community of Practice Manager
eCheminfo InnovationWell cheminformatics chemoinformatics bioinformatics Medicinal Chemistry Computational Chemistry Virtual Screening ADME ADMET toxicology Molecular Modelling Molecular Modeling pharmaceutical pharma meeting workshop training Oxford Critical Path toxicology Bursary Life Sciences Pharma Drug Discovery Research and Development Drug Development Healthcare Innovation Knowledge Management events
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