The Ferryman

eCheminfo workshop will apply OpenTox to generating evidence on potential toxic liabilities in anti-malarial drug design

The upcoming eCheminfo workshop will apply a variety of computational methods to novel anti-malarial drug design.

We will make use of OpenTox resources and applications in generating evidence on potential toxic liabilities in the decision making framework.

More information is provided at http://barryhardy.blogs.com/cheminfostream/2014/06/echeminfo-workshop-will-apply-computational-methods-to-novel-anti-malarial-drug-design.html

eCheminfo drug discovery workshop in Oxford this year will work on anti-malarial case studies

We are organising our next eCheminfo hands-on drug design workshop in Oxford running 21 - 25 July:

http://www.douglasconnect.com/events/echeminfo-2014

Details on the program which we will run at St Hugh's College:
http://www.douglasconnect.com/dd2014/echeminfo2014.pdf

As in previous workshops the emphasis is on problem solving, practical hands-on use of methods and software applied to drug design problems, and working together throughout the week.

This year we will offer a neglected disease case study focus expanding on the initial collaboration activities of the Scientists Against Malaria initiative. We plan to try to develop and test most promising designs and predictions as workshop followup.

 

Related articles

eCheminfo drug discovery workshop, Oxford, 21 - 25 July

eCheminfo Drug Design workshop, bursary

Goodbye Patrik, we will miss you.

How malaria defeats our drugs

ICH M7 Guidance on Assessment of Impurities in Pharmaceutical Products

It is an exciting time for me as I am finally now able to move into our third phase of innovation that you may recall my discussing in meetings past e.g., within InnovationWell.  We have worked with you and many others to patiently develop the foundations of trust, community and collaboration, and now we enter heady and challenging days of developing the innovation ecosystem. I hope you will be able to participate in the partnerships and startups to be launched in coming months and years!

We are about making solutions really work through co-working. In this respect I must personally vouch that the folks at Leadscope have been an excellent partner that have helped advance the ToxBank data management and analysis infrastructure building upon OpenTox as a world leading innovative platform. They have not just talked, they have actually done things, and consistently!  

In this context I am very happy to announce our full committment and collaboration to advancing the area of in silico and in vitro testing as supported by the new FDA regulations for non-active ingredients in drug formulations. This is truly a revolutionary step forward in our field of computational science in terms of regulatory acceptance.

We will hold a first event in Basel April 30 (see below), but can also arrange further face-to-face and virtual events to discuss developing this area further as an emerging best practice. I look forward to our further discussion!

Barry

Seminar on ICH M7 Guidance on Assessment of Impurities in Pharmaceutical Products
April 30, Merian Hotel, Basel, Switzerland
co-organised by Leadscope, USA and Douglas Connect, Switzerland

Our Topic
Is your company planning on implementing the pending ICH M7 impurities guidelines?  The guidelines which are expected to be approved in final form this summer permit the use of genotoxicity QSAR models to replace actual testing.  The guidelines state that a QSAR statistical-based methodology and expert alerts system can be used to predict the outcome of a bacterial mutagenicity assay to support hazard assessment.

Learning objectives
* Understand the scope, process and strategies necessary to support ICH M7-compliant QSAR computational toxicology regulatory submissions
* Appreciate how expert rule-based and statistical-based in silico models operate
* Learn how to generate and combine the results from different in silico systems
* Identify what tools are available to support a chemical and biological interpretation of the results
* Understand components of an expert opinion for conflicting in silico results

Agenda

9:00am - 9:15am Loftus Lucas - Introductions

9:15am - 9:45am Dr. Dan Benz - The ICH M7 Impurities guidelines for QSAR computational toxicology

9:45am - 10:15am Dr. Glenn Myatt - Two complementary in silico methodologies needed to support the ICH M7 Guideline

10:15am - 10:30am Coffee break

10:30am - 11:00am Dr. Dan Benz - Using, interpreting, generating consensus predictions and submitting in silico model results to US FDA

11:00am -11:30am Dr. Barry Hardy - Components of an expert opinion to support a regulatory submission

11:30am - 12:00 pm Roundtable discussion

12:00pm - 1:00pm Lunch

1:00pm - 2:00pm Informal discussions and networking



Please contact us if interested in attending.

http://www.douglasconnect.com/submit-enquiry

OpenTox Euro 2014, Athens, first announcement

The OpenTox Euro 2014 meeting takes place 22 - 24 September in Athens, Greece. The meeting will be co-sponsored by ToxBank and eNanoMapper.

The theme of this year's meeting is industrial and regulatory application of predictive toxicology and includes sessions on read across, integrated testing strategies, systems biology, metabolism, nano safety, data resource management, visualisation and analysis.

The meeting program will include reviewed abstracts for talks and posters and interactive workshop activities and knowledge café discussions.

Information on the meeting including registration, abstract submission, and program and location information can be found at:
http://www.douglasconnect.com/event/opentox-euro-2014

Abstracts for consideration for the speaker program should be submitted by 30 April. Early registration is open through 31 May.


On behalf of the OpenTox Euro 2014 Organising Committee,
we look forward to seeing you in Athens,

Dr. Barry Hardy (Douglas Connect) and Assoc. Prof. Haralambos Sarimveis (National Technical University of Athens)

Related articles

Innovation in Predictive Toxicology

OpenTox Euro 2013 Speaker Program

OpenTox Euro 2013 program

OpenTox USA 2013 program

OpenTox supports event-driven ontology-based Weight of Evidence

OpenTox supports event-driven ontology-based Weight of Evidence.

#opentox #2014SOT #ToxExpo  #ToxBank Visit Douglas Connect booth 1770

 

 

ToxBank uses ISA-Tab to describe a diverse range of biological datasets

ToxBank uses ISA-Tab to describe a diverse range of biological datasets to ensure higher quality analysis #ToxBank #opentox #2014SOT #ToxExpo Visit Douglas Connect booth 1770

 

 

ToxBank supports 75 organisations within SEURAT-1 cluster

ToxBank supports a wide diversity of experimental and modelling activities carried out by 75 organisations within the SEURAT-1 research cluster, which is developing replacement alternatives for safety assessment.

SEURAT-1 is a public-private partnership funded by Cosmetics Europe and the EC.

 

 

#ToxBank Launch at SOT 2014 #opentox #2014SOT #ToxExpo

 

 

Complex (Big Data) Omics Analysis supported by ToxBank

ToxBank provides a unique combination of people and scalable infrastructure enabling Complex (Big Data) Omics Analysis. Come and discuss with us at #sot2014 #opentox #toxbank #toxexpo Demos at Douglas Connect Stand 1770 #opentox

 

ToxBank Launch at SOT 2014

We are launching ToxBank at the SOT 2014 conference in Phoenix, Arizona this week.

ToxBank provides a 21st century data and analysis infrastructure for predictive toxicology.

ToxBank builds on the unique advantages of the OpenTox framework.

Come by the Douglas Connect stand 1770 to try out and discuss.

If you are not at the event please contact us to arrange a virtual meeting.

http://www.toxbank.net/

First ToxBank Tutorial released

We have released the first ToxBank tutorial on Searching the Data Warehouse:

http://www.youtube.com/watch?v=mE54EnY8uB4

More to follow in coming days!