The Ferryman

OpenTox Association activities

Following up on the initial OpenTox project which was funded by the EU under FP7, OpenTox has developed as an open standards platform supporting application and infrastructure development in predictive toxicology and safety assessment. The OpenTox Association was founded 27 March this year as an international member-based non-profit association.

The purpose of the Association is to promote the community-based exchange and use of open knowledge, software, methods, tools, data, reference resources, and standards in the scientific activities of predictive toxicology, safety assessment and risk management, including the 3Rs goal of the Reduction, Refinement and Replacement of Animal Testing. Working groups have been formed which working virtually on an ongoing basis to elaborate further the open standards and integrating resources approach developed by the OpenTox community.

The OpenTox Euro 2015 meeting takes place 30 Sept - 2 Oct in Dublin, Ireland. The conference theme is Reproducible High Quality Safety Science on Complex Systems and will include conference sessions on Information Requirements & Standards, Characterisation of Systems, High Content Screening, Metabolism, Modelling Cellular Perturbations & Responses, Linking Parameters & Evidence across Scales, Simulation, Systems Biology and Knowledge Integration Supporting Decision Making.

OpenTox Association Working group meetings will be held on the topics of Application Programming Interfaces, Adverse Outcome Pathways, Data and Metadata Standards and Resource Deployment. The meeting will also include a General Assembly of the Association in addition to hands-on modelling and analysis sessions, poster session and knowledge cafes.

To submit an abstract for the meeting:
(Deadlines: 31 July for speaker program, 31 August for posters)
http://www.opentox.net/submit-abstract-poster-or-chair

Information and updates on the program will be posted at:
http://www.opentox.net/events/opentox-euro-2015

Barry Hardy
President, OpenTox Association
On behalf of the Organising Committee

More information on the OpenTox Association:
http://www.opentox.net/the-opentox-association

eCheminfo Community of Practice Meeting, Baltimore, USA, 9-11 Feb 2015

http://barryhardy.blogs.com/cheminfostream/2014/10/echeminfo-drug-design-meeting-johns-hopkins-9-11-feb-2015.html

Drug Design in India, Malaria Focus

Drug Design in India, Malaria Focus - we are taking the eCheminfo drug design workshop activities we have developed in Oxford in recent years to India in January.

http://barryhardy.blogs.com/cheminfostream/2014/10/drug-design-in-india-malaria-focus.html

Innovation in Development and Translational Medicine

On the 13 February 2015 we will hold an InnovationWell workshop at Johns Hopkins, Baltimore.

The goal of the workshop is to discuss experiences, practices and solutions in drug development and translational medicine.

We will discuss case study experiences involving collaboration in drug and biotech discovery and development, obstacles experienced in practice and methods used to overcome barriers, approaches used to data sharing including IP and contractual issues, practices in knowledge management and innovation success.

We will subsequently flush out the real problems and issues involved in current practices in translational medicine, identify the strengths and weaknesses in current approaches being used and explore new strategies that might be of use to address and achieve improved translational success.

The workshop will be facilitated by Frank Hollinger (Sphaera Pharma), Michael Liebman (Strategic Medicine) and Barry Hardy (Douglas Connect).

Further information on the program can be found at
http://www.innovationwell.net/events/innovationwell-2015

OpenTox USA 2015

I am pleased to announce the program for the OpenTox USA 2015 meeting which will take place 10-12 Feburary at Johns Hopkins, Baltimore.

The goal of the meeting is to discuss and develop important components for driving 21st century approaches to safety assessment forward. We assume that collaboration driven by an open global platform and open standards will be a key success factor. Integrating heterogenous evidence supported by a common knowledge framework and ecosystem of tools and partners will enable practical application, judgements and decisions including industrial application and regulatory acceptance.

The program will involve conference sessions and associated hands-on workshops, poster session and knowledge cafes.

The main themes of the meeting are:

Data Science, facilitated by Barry Hardy (Douglas Connect)
Adverse Outcome Pathways, facilitated by Stephen Edwards (US EPA)
Exposure Modelling, facilitated by Tim Pastoor (Syngenta)
Integrating Evidence and Analysis, Thomas Hartung (Johns Hopkins)
Risk Assessment & Management Applications, Grace Patlewicz (Du Pont)

We are open for submission of abstracts for consideration for the program.

Further information on the program can be found at
http://www.opentox.com/events/opentox-usa-2015

On behalf of the OpenTox Community and the Organising Committee.

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eCheminfo workshop will apply OpenTox to generating evidence on potential toxic liabilities in anti-malarial drug design

The upcoming eCheminfo workshop will apply a variety of computational methods to novel anti-malarial drug design.

We will make use of OpenTox resources and applications in generating evidence on potential toxic liabilities in the decision making framework.

More information is provided at http://barryhardy.blogs.com/cheminfostream/2014/06/echeminfo-workshop-will-apply-computational-methods-to-novel-anti-malarial-drug-design.html

eCheminfo drug discovery workshop in Oxford this year will work on anti-malarial case studies

We are organising our next eCheminfo hands-on drug design workshop in Oxford running 21 - 25 July:

http://www.douglasconnect.com/events/echeminfo-2014

Details on the program which we will run at St Hugh's College:
http://www.douglasconnect.com/dd2014/echeminfo2014.pdf

As in previous workshops the emphasis is on problem solving, practical hands-on use of methods and software applied to drug design problems, and working together throughout the week.

This year we will offer a neglected disease case study focus expanding on the initial collaboration activities of the Scientists Against Malaria initiative. We plan to try to develop and test most promising designs and predictions as workshop followup.

 

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OpenTox Euro 2014, Athens, first announcement

The OpenTox Euro 2014 meeting takes place 22 - 24 September in Athens, Greece. The meeting will be co-sponsored by ToxBank and eNanoMapper.

The theme of this year's meeting is industrial and regulatory application of predictive toxicology and includes sessions on read across, integrated testing strategies, systems biology, metabolism, nano safety, data resource management, visualisation and analysis.

The meeting program will include reviewed abstracts for talks and posters and interactive workshop activities and knowledge café discussions.

Information on the meeting including registration, abstract submission, and program and location information can be found at:
http://www.douglasconnect.com/event/opentox-euro-2014

Abstracts for consideration for the speaker program should be submitted by 30 April. Early registration is open through 31 May.


On behalf of the OpenTox Euro 2014 Organising Committee,
we look forward to seeing you in Athens,

Dr. Barry Hardy (Douglas Connect) and Assoc. Prof. Haralambos Sarimveis (National Technical University of Athens)

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ToxBank uses ISA-Tab to describe a diverse range of biological datasets to ensure higher quality analysis #ToxBank #opentox #2014SOT #ToxExpo Visit Douglas Connect booth 1770

 

 

First ToxBank Tutorial released

We have released the first ToxBank tutorial on Searching the Data Warehouse:

http://www.youtube.com/watch?v=mE54EnY8uB4

More to follow in coming days!